Monday, 28th October 29th Australian and New Zealand Bone and Mineral Society Annual Scientific Meeting 2019

Breakfast served outside of room for attendees of this session.

• Update from the ANZBMS Therapeutics Committee - Richard Prince
• Sclerostin Inhibitors in the Management of Osteoporosis: A New Dawn? - Christian Girgis
• The hidden cost of cancer treatment: optimising bone health for women with breast cancer. - Emma Duncan
• Burosumab: role in management of X-linked hypophosphataemic rickets. - Craig Munns

The conference acknowledges the support of

• Long-term Management of Osteoporosis - Bente Langdahl
• Fixing a Fractured Service: Improving Osteoporosis Management - Charles Inderjeeth
• Canaries in the coalmine? The diverse roles of observational epidemiology in understanding bone health - Tania Winzenberg
• Perspectives on bone health in youth - Aris Siafarikas

• The systemic effect of Parathyroid Hormone and Alendronate on femoral bone volume in the rat ulnar stress fracture model - Mahmoud M Bakr
• Deciphering the Secretory Lysosome ‘Transportome’ Unveils Novel Regulators of Osteoclast Function and Bone Homeostasis - Amy B P Ribet
• Osteoporosis in premature ovarian insufficiency: Clinicians’ knowledge gaps and barriers to care. - Alicia R Jones
• Altered trabecular bone mineral properties of subchondral bone marrow lesions in knee osteoarthritis patients - Yea Rin Olivia Lee
• Muscle performance improves predictive accuracy of the Garvan fracture risk calculator: A reclassification analysis - Dima Alajlouni
• Upregulated macrophage distribution in reduced osteonecrosis of the jaw-like lesions by the discontinuation of anti-RANKL antibody in mice. - Saki Tamaki
• Utility of an automated vertebral fracture detection software - Nithin Kolanu
• Evaluation of bone microstructure of distal radius and distal tibia on human objects using phase-contrast synchrotron radiation computed tomography - Ali Ghasem-Zadeh
• Mood disorders and antidepressant use are associated with trabecular bone score in women - Kara B Anderson

Professor Michael McClung
Transitioning and sequencing osteoporosis treatments

This session is supported and organised by

• Epigenetic Regulation of Mesenchymal Stem Cell Differentiation, Skeletal Development and Ageing - Stan Gronthos
• Uncovering a new case of human malignant osteopetrosis and its mechanistic insights - Jiake Xu
• Neurogenic heterotopic ossifications following spinal cord injuries are derived from fibro-adipogenic progenitors in the skeletal muscle not from satellite cells - Jean-Pierre Levesque
• Serum CTX-1 levels to predict smouldering myeloma patients at high risk of progression to multiple myeloma - Melissa D Cantley
• Increased Osteoclast activity precedes rebound bone loss following withdrawal of rankl inhibition. - Michelle M McDonald
• Effects of calcium supplementation on long-term changes in high sensitivity cardiac troponin I in older women: analysis from a 5 year double-blind randomised controlled trial   - Joshua R Lewis
• Severely Decreased Bone Formation in the Winnie Mouse Model of Inflammatory Bowel Disease (IBD) - Ahmed Al Saedi

Associations of fat mass and overweight status in childhood and early adulthood with bone mineral density and microarchitecture in early adulthood - Benny Antony

Osteoporosis in premature ovarian insufficiency: Clinicians’ knowledge gaps and barriers to care. - Alicia R Jones

Muscle performance improves predictive accuracy of the Garvan fracture risk calculator: A reclassification analysis - Dima Alajlouni

Utility of an automated vertebral fracture detection software - Nithin Kolanu

Mood disorders and antidepressant use are associated with trabecular bone score in women - Kara B Anderson

• An unusual case of transient alkaline hyperphosphatasemia in an adult: a diagnostic dilemma and a commentary on the utility of alkaline phosphatase isoenzyme assays - Difei Deng
• Metastatic pulmonary calcification: An unusual presentation of respiratory failure - Swee Ping Teh
• A Calcium Conundrum - Jade Eccles-Smith
• Hypophosphataemia mimicking ankylosing spondylitis - Jianna He
• Multiple Brown tumours and fragility fractures following the withdrawal of cinacalcet for management of secondary hyperparathyroidism due to end stage renal disease - Kai Aun Lim
• Pseudohypoparathyroidism Type 1b -Exploration of molecular genetics and the role of genetic testing - Aakansha Zala
• Persistent urinary phosphate wasting post renal transplant- bone implications - Melanie Light
• Asia-Pacific consortium on osteoporosis: IQ driving QI-innovative collaborative initiatives to improve osteoporosis care in the Asia-Pacific region - Peter R Ebeling
• Hemoglobin levels are low in osteosarcopenic older patients - Ebrahim Bani Hassan
• Increasing green leafy vegetables containing vitamin K1 reduces the total and the undercarboxylated fraction of osteocalcin: a 4-week randomised control trial - Marc Sim
• Bone material strength index is associated with prior fracture in men with and without moderate to severe chronic kidney disease - Kara Anderson
• The reliability of dual-energy X-ray absorptiometry measurements of bone mineral density in the later distal femur of children with Cerebral Palsy. - Camilla P Davenport
• Fracture risk and mortality from Type 2 Diabetes in the Canadian Multicentre Osteoporosis study (CaMos) - Nithin Kolanu
• Associations between health literacy in men and sharing of DXA results with doctors - Natalie K Hyde
• Higher concentrations of parathyroid hormone (PTH) are associated with reduced gait velocity in adults a systematic review - Lavanya Srinivasa Murthy
• Constitutive melanin density is associated with prevalent and short-term, but not long-term, incident fracture risk in older Caucasian adults - Michael Thompson
• A study of the early effect of an optimal dose of NSAIDs in treatment of early axial SpA patients - Fatma Fayed
• Please Don’t Move - feasibility of automatically evaluating motion artefact from peripheral Quantitative Computed Tomography scans using a deep learning approach - Paola Chivers
• Atypical femoral fractures - are bisphosphonates the only culprit   - Aiden Cushnahan
• Supporting those experiencing chronic musculoskeletal pain to re-engage with work: Road-mapping the co-design phase undertaken by community, researchers, government, and policy influencers - Sharon L Brennan-Olsen
• Personalised 3D-printed titanium implants for limb-salvage osteosarcoma surgery - Victoria D Leitch
• The cross-sectional and longitudinal associations of dietary patterns with knee symptoms and MRI detected structure in patients with knee osteoarthritis - Shuang Zheng
• Progressive increase in bone turnover despite improvement in markers of calcium homeostasis over twelve months post sleeve gastrectomy in obese subjects - Chris Kwan
• Does the degree of radiographic erosive disease affect the interreader agreement of erosion score using HR-pQCT? - Anne-Birgitte Blavnsfeldt
• Measures of physical performance as a predictor of fracture risk independent of BMD change: the Chungju Metabolic Disease Cohort study - Yejee Lim
• Antidepressants use and incident fracture: a 10.7-year follow-up study - Feng Pan
• Falls in community-dwelling women with bipolar disorder - Kara Anderson
• Glycaemic control in pregnancy and offspring bone measures: The Vitamin D in Pregnancy Study   - Natalie K Hyde
• Introducing a fracture liaison service: establishing baseline absolute risk of subsequent fracture - Steve A Frost
• Small individual-level increase in bone mineral density translated into substantial population-level decrease in fracture incidence: revisiting Goeffrey Rose's axiom - Thach Tran
• Effect of short-term hypoxia on human osteoblast-like SaOs-2 cells in vitro - Rita Hameister
• Effects of cell transplantation on BRONJ-like lesions are quite different between SVF cells and QQ-MNCs - Shinichiro Kuroshima
• Generating a toolbox for screening genetic variants associated with bone fragility disorders - Alexandra O'Donohue
• Osteoadherin plays roles in the regulation of apoptosis and growth in MC3T3-E1 osteoblast cells - Eri Hamaya
• Undercarboxylated osteocalcin and vascular function in normal and high glucose environments - Itamar Levinger
• Developing a cell line model of osteocyte infection - Nicholas J Gunn
• The effect of Alzheimer’s disease on the bone: it’s a lose lose situation - Catherine J M Stapledon
• Methotrexate chemotherapy alters Notch signaling in the bone in rats - Yaser Peymanfar
• Tibia cartilage thickness, cortical thickness and subchondral bone microarchitecture: varus- and valgus-aligned osteoarthritic knees vs. controls  - Egon Perilli
• Targeted mechanical loading of stable sclerotic and osteolytic vertebral bone metastases is safe for patients with advanced prostate or breast cancer. - Nicolas Hart
• Predicting failure to attend: lessons learnt from the first year in a fracture liaison service (FLS) - Allison Sigmund

• Wnt-mediated mechanisms of diabetic bone disease. - Martina Rauner
• The osteoblast as an energy and nutrient sensing cell. - Paul Baldock
• Sarcopenia and obesity: associations with fracture risk in older adults - David Scott
• Relationship between visceral adipose tissue and bone mineral density in middle to older age Australians - Kun (Kathy) Zhu
• PYY is a negative regulator of bone mass and strength - Victoria D Leitch
• Post-menopausal women with high visceral fat levels exhibit impaired bone turnover and altered bone resorption in response to acute calcium consumption.   - Deepti Sharma
• Endoplasmic reticulum mediates mitochondrial transfer within the osteocyte dendritic network - Junjie Gao
• Cardiovascular safety of denosumab versus bisphosphonates or placebo in post-menopausal women: systematic review and meta-analysis - Alexander H. Seeto

No longer fracturing over a cup of tea: remarkable improvement in bone health and functional status in an adult with hypophosphatasia treated with asfotase alfa. - Jordyn Mahanga
Lessons learnt from delayed diagnosis of FGF-23-producing tumour-induced osteomalacia and post-operative hungry bone syndrome - Shejil Kumar
Chronic kidney disease-mineral and bone disorder (CKD-MBD) and delayed puberty: a case of renal and gonadal dysgenesis - Genevieve L Calder
Hypophosphataemia in the newborn: a peculiar cause - Emily Papadimos
A bony conundrum that keeps on growing: The ABCs of PFD - Matthew Balcerek
A case of drug-induced osteomalacia - Senthil Thillainadesan