Digital transformation will enable personalized exercise intervention for promoting bone strength in individual patients. In this context, the complex hierarchical and multi-physics interdependences between bone geometry, distribution, mechano-adaptation and exercise physiology complicates obtaining comprehensive description of musculoskeletal functional adaptation. Here, the advances made by integrating imaging and motion capture with knowledge of bone mechanics and adaptation into models of femoral adaptation and fracture will be discussed. The separate contribution of each muscle to the mechanical stimulus in the bone while performing various types of normal exercise will be analysed providing generic exercise recommendations for promoting hip strength. The clinical viability of digital technology will be then discussed in terms of current applications, potentials and challenges.