Poster Presentation 29th Australian and New Zealand Bone and Mineral Society Annual Scientific Meeting 2019

Higher concentrations of parathyroid hormone (PTH) are associated with reduced gait velocity in adults a systematic review (#126)

Lavanya Srinivasa Murthy 1 , NATASHA A Grande de França 2 , GUILLAUME T DUVAL 3 , SARA VOGRIN 1 4 , CEDRIC ANNWEILER 3 5 , GUSTAVO DUQUE 1 4
  1. Australian Institute for Musculoskeletal Science (AIMSS), The University of Melbourne and Western Health, . , ST.ALBANS, VIC, Australia
  2. Department of Nutrition, School of Public Health, University of São Paulo, São Paulo, Brazil.
  3. Department of Neuroscience and Aging, , Division of Geriatric Medicine and Memory Clinic; Research Centre on Autonomy and Longevity; Angers University Hospital; University of Angers,, Angers, France
  4. Department of Medicine, Western Health, Melbourne Medical School, The University of Melbourne, , ST.ALBANS, VIC, Australia
  5. Department of Neuroscience and Aging, , Division of Geriatric Medicine and Memory Clinic; Research Centre on Autonomy and Longevity; Angers University Hospital; University of Angers,, Angers, France

Introduction/Objectives: High serum concentrations of parathyroid hormone (PTH) have been associated with osteosarcopenia. Gait velocity is a predictor of adverse outcomes in osteosarcopenic subjects. This systematic review aimed to assess evidence for the effect of high PTH levels  on gait velocity in adults.

Methods: We searched PubMed, Embase (Ovid interface) and Cochrane (CENTRAL) for published studies evaluating circulating PTH in human adults aged >20years, without date or language restriction.  We excluded studies with patients on dialysis and if PTH was measured following any intervention having potential effect on its concentrations. Primary outcome was gait velocity defined as the time needed to walk a predetermined distance, or distance walked during a fixed period at usual pace or fast pace. Two independent researchers conducted data extraction and evaluated the risk of bias. Disagreements were resolved by a third reviewer. Risk of bias assessment was done using the National Heart, Lung and Blood Institute quality assessment tool.

Results: A total of 681 articles were retrieved from the systematic search. Following full text review and risk of bias assessment, 8 studies were included for final analysis. Of the included studies, half (n=4) demonstrated a significant inverse association between high PTH concentrations and gait velocity, one study showed a nonsignificant association of increasing PTH levels with declining gait speed, and the remainder showed no relation. In addition, three studies also highlighted a negative correlation between PTH levels and muscle strength.

Conclusion: Our review of published studies suggests higher concentrations of PTH are associated with reduced gait velocity in adults. This relationship deserves further exploration with RCTs designed to assess the effects of correcting abnormal circulating PTH levels on physical performance in adults.